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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPX2
All Species:
19.39
Human Site:
T499
Identified Species:
42.67
UniProt:
Q9ULW0
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9ULW0
NP_036244.2
747
85653
T499
K
N
R
I
R
M
P
T
K
E
D
E
E
E
D
Chimpanzee
Pan troglodytes
XP_001153533
746
85517
T498
K
N
R
I
R
M
P
T
K
E
D
E
E
E
D
Rhesus Macaque
Macaca mulatta
XP_001109645
746
85683
T498
K
N
R
I
R
M
P
T
K
E
D
E
E
E
D
Dog
Lupus familis
XP_850934
748
86144
T500
K
N
R
I
R
M
P
T
K
E
D
E
E
E
E
Cat
Felis silvestris
Mouse
Mus musculus
NP_082385
745
85876
I499
K
N
R
I
R
V
P
I
K
D
E
E
E
E
K
Rat
Rattus norvegicus
NP_001101260
744
85432
V497
K
N
R
I
R
V
P
V
K
E
D
E
E
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516385
623
69684
E451
E
T
W
K
Q
Q
L
E
E
D
L
R
Q
Q
K
Chicken
Gallus gallus
NP_989768
739
85048
S497
K
S
R
T
R
M
T
S
R
D
E
E
K
E
K
Frog
Xenopus laevis
NP_001086751
715
81991
A468
K
N
R
V
R
I
P
A
Q
E
E
K
E
E
E
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798362
948
108486
E704
K
N
R
V
R
V
K
E
D
V
I
V
E
P
E
Poplar Tree
Populus trichocarpa
XP_002327911
811
91572
S566
F
D
K
L
S
L
R
S
E
P
I
L
D
N
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97.5
90.3
N.A.
79.2
79.1
N.A.
40.1
57.5
53.8
N.A.
N.A.
N.A.
N.A.
N.A.
31.6
Protein Similarity:
100
99.3
98.6
93.9
N.A.
87.6
87.4
N.A.
53
72.5
70
N.A.
N.A.
N.A.
N.A.
N.A.
49.4
P-Site Identity:
100
100
100
93.3
N.A.
66.6
80
N.A.
0
40
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
P-Site Similarity:
100
100
100
100
N.A.
86.6
93.3
N.A.
40
80
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
53.3
Percent
Protein Identity:
20.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
39.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
0
10
28
46
0
10
0
28
% D
% Glu:
10
0
0
0
0
0
0
19
19
55
28
64
73
73
37
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
55
0
10
0
10
0
0
19
0
0
0
0
% I
% Lys:
82
0
10
10
0
0
10
0
55
0
0
10
10
0
28
% K
% Leu:
0
0
0
10
0
10
10
0
0
0
10
10
0
0
0
% L
% Met:
0
0
0
0
0
46
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
73
0
0
0
0
0
0
0
0
0
0
0
10
0
% N
% Pro:
0
0
0
0
0
0
64
0
0
10
0
0
0
10
10
% P
% Gln:
0
0
0
0
10
10
0
0
10
0
0
0
10
10
0
% Q
% Arg:
0
0
82
0
82
0
10
0
10
0
0
10
0
0
0
% R
% Ser:
0
10
0
0
10
0
0
19
0
0
0
0
0
0
0
% S
% Thr:
0
10
0
10
0
0
10
37
0
0
0
0
0
0
0
% T
% Val:
0
0
0
19
0
28
0
10
0
10
0
10
0
0
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _